InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ilf3

Summary

InnateDB Protein

IDBP-140181.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ilf3

Protein Name

interleukin enhancer binding factor 3

Synonyms

MBII-26; MPHOSPH4; NF90; NFAR;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000065770

InnateDB Gene

IDBG-140179 (Ilf3)

Protein Structure

UniProt Annotation

Function

May facilitate double-stranded RNA-regulated gene expression at the level of post-transcription. Can act as a translation inhibitory protein which binds to coding sequences of acid beta-glucosidase (GCase) and other mRNAs and functions at the initiation phase of GCase mRNA translation, probably by inhibiting its binding to polysomes. Can regulate protein arginine N- methyltransferase 1 activity. Can promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA (By similarity). The phosphorylated form at Thr-188 and Thr-315, in concert with EIF2AK2/PKR can inhibit vesicular stomatitis virus (VSV) replication. {ECO:0000250, ECO:0000269PubMed:21123651}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Cytoplasm {ECO:0000269PubMed:21123651}. Nucleus {ECO:0000269PubMed:21123651}. Note=The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Disease Associations

Tissue Specificity

Ubiquitous. Expressed at high levels in the thymus, testis, ovary and at lower levelss in the spleen.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 245 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	245 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006479	protein methylation
GO:0017148	negative regulation of translation
GO:0045071	negative regulation of viral genome replication
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051607	defense response to virus