InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ilf3

Summary

InnateDB Gene

IDBG-140179.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ilf3

Gene Name

interleukin enhancer binding factor 3

Synonyms

MBII-26; MPHOSPH4; NF90; NFAR

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032178

Encoded Proteins

IDBP-140181

interleukin enhancer binding factor 3

IDBP-249682

interleukin enhancer binding factor 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18490444

[Homo sapiens] ILF3 is an RNA-binding protein that influences mRNA turnover and/or translation by regulating mRNA stability. ILF3 can bind to mitogen-activated protein (MAP) kinase phosphatase 1 (MKP-1) and increase its mRNA stability and translation, resulting in increased MKP-1 dephosphorylation activity and thereby inactivation of MAP kinases extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38.

Entrez Gene

Summary

The protein encoded by this gene contains two double-stranded RNA binding domains and functions in the post-transcriptional regulation of gene expression. It is a component of an RNA-protein complex that may be involved in mediating the export of messenger RNAs. Alternative splicing results in multiple transcript variants encoding distinct isoforms. These isoforms are grouped into two categories, NFAR-1 or NFAR-2, based on variation at the C-terminus. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:21368019-21405361

Strand

Forward strand

Band

Transcripts

ENSMUST00000067646	ENSMUSP00000065770
ENSMUST00000115414	ENSMUSP00000111074

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 245 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	11 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	245 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006479	protein methylation
GO:0017148	negative regulation of translation
GO:0045071	negative regulation of viral genome replication
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0051607	defense response to virus

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000129351

View Gene Order

ENSBTAG00000040076

Not yet available

Cross-References

SwissProt

TrEMBL

Q45VK5

UniProt Splice Variant

Entrez Gene

16201

UniGene

Mm.440026 Mm.470594

RefSeq

NM_001042708 NM_001042709 NM_001042707 NM_001277321 NM_001277322 NM_010561 XM_006510029 XM_006510030 XM_006510031

OMIM

CCDS

CCDS40553 CCDS40552

HPRD

IMGT

MGI ID

MGI:1339973

MGI Symbol

Ilf3

EMBL

AC122525 DQ104406

GenPept

AAZ20652

RNA Seq Atlas

16201