Version 5.4
Mus musculus Protein: Pde12
Summary
InnateDB Protein IDBP-140207.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pde12
Protein Name phosphodiesterase 12
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000059666
InnateDB Gene IDBG-140205 (Pde12)
Protein Structure
UniProt Annotation
Function Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferon (IFNs) (By similarity). {ECO:0000250}.
Subcellular Localization Mitochondrion matrix {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004535 poly(A)-specific ribonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006397 mRNA processing
GO:0008150 biological_process
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID MGI:2443226
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
PFAM PF03372
PF14529
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3TIU4
PhosphoSite PhosphoSite-Q3TIU4
TrEMBL
UniProt Splice Variant
Entrez Gene 211948
UniGene Mm.474327
RefSeq NP_848783
MGI ID
MGI Symbol Pde12
OMIM
CCDS CCDS26882
HPRD
IMGT
EMBL AK051991 AK082947 AK088843 AK155088 AK161083 AK167708 BC064450
GenPept AAH64450 BAC34827 BAC38703 BAC40606 BAE33039 BAE36189 BAE39752

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca