Version 5.4
Mus musculus Gene: Pde12
Summary
InnateDB Gene IDBG-140205.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pde12
Gene Name phosphodiesterase 12
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000043702
Encoded Proteins
IDBP-140207
phosphodiesterase 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26055709
[Homo sapiens] PDE12 negatively regulates the innate immune response and inhibitors of PDE12 show increased IFN induced 2â??,5â??- oligoadenylate and antiviral activities.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174840:
Gene Information
Type Protein coding
Genomic Location Chromosome 14:26659958-26669883
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000052932 ENSMUSP00000059666
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004535 poly(A)-specific ribonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006397 mRNA processing
GO:0008150 biological_process
GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000174840
View Gene Order
ENSBTAG00000015563
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.290758 Mm.297768 Mm.474327
RefSeq NM_178668
OMIM
CCDS CCDS26882
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca