Mus musculus Protein: Slc22a6 | |||||||||||||||||||||
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Summary | |||||||||||||||||||||
InnateDB Protein | IDBP-140315.6 | ||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||
Gene Symbol | Slc22a6 | ||||||||||||||||||||
Protein Name | solute carrier family 22 (organic anion transporter), member 6 | ||||||||||||||||||||
Synonyms | mOat1; NKT; Oat1; Orctl1; | ||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||
Ensembl Protein | ENSMUSP00000010250 | ||||||||||||||||||||
InnateDB Gene | IDBG-140313 (Slc22a6) | ||||||||||||||||||||
Protein Structure | |||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||
Function | Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS), cidofovir, adefovir, 9-(2-phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP), ochratoxin (OTA), acyclovir (ACV), 3'-azido-3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5- propyl-2-furanpropionate (CMPF) and edaravone sulfate (By similarity). Mediates the sodium-independent uptake of p- aminohippurate (PAH). PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, bumetamide, losartan, probenecid, phenol red, urate, glutarate and alpha-ketoglutarate (By similarity). PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), indomethacin, sulindac, diclofenac, carprofen, okadaic acid and PKC activators. {ECO:0000250, ECO:0000269PubMed:10744714, ECO:0000269PubMed:14979872, ECO:0000269PubMed:9880528}. | ||||||||||||||||||||
Subcellular Localization | Cell membrane {ECO:0000269PubMed:9045672}; Multi-pass membrane protein {ECO:0000269PubMed:9045672}. Note=Localized to the plasma membrane. | ||||||||||||||||||||
Disease Associations | |||||||||||||||||||||
Tissue Specificity | Expressed in kidney; in the basolateral membrane and at much lower levels in brain. {ECO:0000269PubMed:9045672, ECO:0000269PubMed:9880528}. | ||||||||||||||||||||
Comments | |||||||||||||||||||||
Interactions | |||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||
PDB ID | MGI:892001 | ||||||||||||||||||||
InterPro |
IPR004749
Organic cation transport protein IPR005828 General substrate transporter IPR011701 Major facilitator superfamily IPR016196 Major facilitator superfamily domain, general substrate transporter IPR020846 Major facilitator superfamily domain |
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PFAM |
PF00083
PF07690 |
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PRINTS | |||||||||||||||||||||
PIRSF | |||||||||||||||||||||
SMART | |||||||||||||||||||||
TIGRFAMs | |||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||
Modification | |||||||||||||||||||||
Cross-References | |||||||||||||||||||||
SwissProt | Q8VC69 | ||||||||||||||||||||
PhosphoSite | PhosphoSite-Q8VC69 | ||||||||||||||||||||
TrEMBL | |||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||
Entrez Gene | 18399 | ||||||||||||||||||||
UniGene | Mm.30090 | ||||||||||||||||||||
RefSeq | NP_032792 | ||||||||||||||||||||
MGI ID | |||||||||||||||||||||
MGI Symbol | Slc22a6 | ||||||||||||||||||||
OMIM | |||||||||||||||||||||
CCDS | CCDS29538 | ||||||||||||||||||||
HPRD | |||||||||||||||||||||
IMGT | |||||||||||||||||||||
EMBL | AK035971 BC021647 U52842 | ||||||||||||||||||||
GenPept | AAC53112 AAH21647 BAC29261 | ||||||||||||||||||||