Version 5.4
Mus musculus Protein: Slc20a2
Summary
InnateDB Protein IDBP-140773.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc20a2
Protein Name solute carrier family 20, member 2
Synonyms MolPit2; Pit-2; Pit2; Ram-1; Ram1;
Species Mus musculus
Ensembl Protein ENSMUSP00000065935
InnateDB Gene IDBG-140771 (Slc20a2)
Protein Structure
UniProt Annotation
Function Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not siginificantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage and vascular calcification. Functions as a retroviral receptor (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Widely expressed including intestine, kidney, heart, liver, brain, testis and skin. Expressed throughout the vertcal crypt-axial axis of intestinal epithelium. {ECO:0000269PubMed:11003594}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005315 inorganic phosphate transmembrane transporter activity
GO:0015293 symporter activity
Biological Process
GO:0006814 sodium ion transport
GO:0006817 phosphate ion transport
GO:0016032 viral process
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:97851
InterPro IPR001204 Phosphate transporter
PFAM PF01384
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80UP8
PhosphoSite PhosphoSite-Q80UP8
TrEMBL P70456
UniProt Splice Variant
Entrez Gene 20516
UniGene Mm.408526
RefSeq NP_035524
MGI ID
MGI Symbol Slc20a2
OMIM
CCDS CCDS22178
HPRD
IMGT
EMBL AC140326 AC153017 AF196476 AK157206 AK170985 BC046510 U62560
GenPept AAB06047 AAG28493 AAH46510 BAE33999 BAE42159

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca