InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spry1

Summary

InnateDB Protein

IDBP-140826.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spry1

Protein Name

sprouty homolog 1 (Drosophila)

Synonyms

sprouty1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000049292

InnateDB Gene

IDBG-140824 (Spry1)

Protein Structure

UniProt Annotation

Function

May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis.

Subcellular Localization

Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).

Disease Associations

Tissue Specificity

Expressed in the embryo and adult tissues including heart, brain, lung, kidney, and skeletal muscle.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000132	establishment of mitotic spindle orientation
GO:0001656	metanephros development
GO:0001657	ureteric bud development
GO:0001759	organ induction
GO:0007275	multicellular organismal development
GO:0008285	negative regulation of cell proliferation
GO:0009966	regulation of signal transduction
GO:0034261	negative regulation of Ras GTPase activity
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0043407	negative regulation of MAP kinase activity
GO:0046580	negative regulation of Ras protein signal transduction
GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway
GO:0060449	bud elongation involved in lung branching
GO:0070373	negative regulation of ERK1 and ERK2 cascade