InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SETMAR

Summary

InnateDB Protein

IDBP-14105.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SETMAR

Protein Name

SET domain and mariner transposase fusion gene

Synonyms

HsMar1; Mar1; METNASE;

Species

Homo sapiens

Ensembl Protein

ENSP00000373354

InnateDB Gene

IDBG-14103 (SETMAR)

Protein Structure

UniProt Annotation

Function

Histone methyltransferase that methylates 'Lys-4' and 'Lys-36' of histone H3, 2 specific tags for epigenetic transcriptional activation. Specifically mediates dimethylation of H3 'Lys-36'. Has sequence-specific DNA-binding activity and recognizes the 19-mer core of the 5'-terminal inverted repeats (TIRs) of the Hsmar1 element. Has DNA nicking activity. Has in vivo end joining activity and may mediate genomic integration of foreign DNA. {ECO:0000269PubMed:16332963, ECO:0000269PubMed:16672366, ECO:0000269PubMed:17403897, ECO:0000269PubMed:17877369, ECO:0000269PubMed:20521842}.

Subcellular Localization

Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.

Disease Associations

Tissue Specificity

Widely expressed, with highest expression in placenta and ovary and lowest expression in skeletal muscle. {ECO:0000269PubMed:16332963}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004519	endonuclease activity
GO:0004803	transposase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0042803	protein homodimerization activity
GO:0043566	structure-specific DNA binding

Biological Process

GO:0000729	DNA double-strand break processing
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006313	transposition, DNA-mediated
GO:0015074	DNA integration
GO:0034968	histone lysine methylation
GO:0071157	negative regulation of cell cycle arrest
GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining
GO:2001251	negative regulation of chromosome organization

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome

Protein Structure and Domains

PDB ID

InterPro

IPR001214 SET domain
IPR001888 Transposase, type 1
IPR002492 Transposase, Tc1-like
IPR002622 Transposase, Synechocystis PCC 6803
IPR003606 Pre-SET zinc-binding sub-group
IPR003616 Post-SET domain
IPR007728 Pre-SET domain
IPR009057 Homeodomain-like

PFAM

PF00856
PF01359
PF01498
PF01710
PF05033

PRINTS

PIRSF

SMART

SM00317
SM00468
SM00508

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q53H47