InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SETMAR

Summary

InnateDB Gene

IDBG-14103.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SETMAR

Gene Name

SET domain and mariner transposase fusion gene

Synonyms

HsMar1; Mar1; METNASE

Species

Homo sapiens

Ensembl Gene

ENSG00000170364

Encoded Proteins

IDBP-14105

SET domain and mariner transposase fusion gene

IDBP-27163

SET domain and mariner transposase fusion gene

IDBP-360813

SET domain and mariner transposase fusion gene

IDBP-360815

SET domain and mariner transposase fusion gene

IDBP-360817

SET domain and mariner transposase fusion gene

IDBP-360819

SET domain and mariner transposase fusion gene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a fusion protein that contains an N-terminal histone-lysine N-methyltransferase domain and a C-terminal mariner transposase domain. The encoded protein binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The SET domain portion of this protein specifically methylates histone H3 lysines 4 and 36. This gene exists as a fusion gene only in anthropoid primates, other organisms lack mariner transposase domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:4303304-4317567

Strand

Forward strand

Band

p26.1

Transcripts

ENST00000358065	ENSP00000373354
ENST00000358950	ENSP00000369673
ENST00000413809	ENSP00000393044
ENST00000425046	ENSP00000397463
ENST00000430981	ENSP00000403000
ENST00000425863	ENSP00000403145
ENST00000490691
ENST00000462115

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004519	endonuclease activity
GO:0004803	transposase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0018024	histone-lysine N-methyltransferase activity
GO:0042803	protein homodimerization activity
GO:0043566	structure-specific DNA binding

Biological Process

GO:0000729	DNA double-strand break processing
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006313	transposition, DNA-mediated
GO:0015074	DNA integration
GO:0034968	histone lysine methylation
GO:0071157	negative regulation of cell cycle arrest
GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining
GO:2001251	negative regulation of chromosome organization

Cellular Component

GO:0005634	nucleus
GO:0005694	chromosome

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000034639

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

hsa00310

Lysine degradation pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001243723 NM_001276325 NM_006515 XM_006713293

HUGO

OMIM

CCDS

CCDS2563 CCDS58814 CCDS63528

HPRD

10225

IMGT

EMBL

GenPept

RNA Seq Atlas