InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LIPC

Summary

InnateDB Protein

IDBP-14110.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIPC

Protein Name

lipase, hepatic

Synonyms

HDLCQ12; HL; HTGL; LIPH;

Species

Homo sapiens

Ensembl Protein

ENSP00000299022

InnateDB Gene

IDBG-14108 (LIPC)

Protein Structure

UniProt Annotation

Function

Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin.

Subcellular Localization

Secreted.

Disease Associations

Hepatic lipase deficiency (HL deficiency) [MIM:614025]: A disorder characterized by elevated levels of beta-migrating very low density lipoproteins, and abnormally triglyceride-rich low and high density lipoproteins. {ECO:0000269PubMed:10660332, ECO:0000269PubMed:1301939}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 24 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	24 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004620	phospholipase activity
GO:0004806	triglyceride lipase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0016298	lipase activity
GO:0030169	low-density lipoprotein particle binding
GO:0034185	apolipoprotein binding
GO:0052689	carboxylic ester hydrolase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006633	fatty acid biosynthetic process
GO:0008203	cholesterol metabolic process
GO:0019433	triglyceride catabolic process
GO:0030301	cholesterol transport
GO:0034372	very-low-density lipoprotein particle remodeling
GO:0034373	intermediate-density lipoprotein particle remodeling
GO:0034374	low-density lipoprotein particle remodeling
GO:0034375	high-density lipoprotein particle remodeling
GO:0034382	chylomicron remnant clearance
GO:0034638	phosphatidylcholine catabolic process
GO:0042632	cholesterol homeostasis
GO:0043691	reverse cholesterol transport
GO:0070328	triglyceride homeostasis

Cellular Component

GO:0005615	extracellular space
GO:0034364	high-density lipoprotein particle

Protein Structure and Domains

PDB ID

InterPro

IPR000734 Lipase
IPR001024 PLAT/LH2 domain
IPR002330 Lipoprotein lipase
IPR002333 Hepatic lipase
IPR008976 Lipase/lipooxygenase, PLAT/LH2
IPR013818 Lipase, N-terminal
IPR016272 Lipoprotein lipase, LIPH
IPR029058 Alpha/Beta hydrolase fold

PFAM

PF01477
PF00151

PRINTS

PR00821
PR00822
PR00824

PIRSF

PIRSF000865

SMART

SM00308

TIGRFAMs

Post-translational Modifications

Modification

Cross-References