InnateDB Protein
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IDBP-14116.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CIRBP
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Protein Name
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cold inducible RNA binding protein
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Synonyms
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CIRP;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000322887
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InnateDB Gene
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IDBG-14114 (CIRBP)
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Protein Structure
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Function |
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold- induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed. {ECO:0000250, ECO:0000269PubMed:11574538, ECO:0000269PubMed:16513844}.
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Subcellular Localization |
Nucleus, nucleoplasm {ECO:0000269PubMed:11574538}. Cytoplasm {ECO:0000269PubMed:11574538}. Note=Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Ubiquitous.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
52
[view]
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Protein-Protein |
52
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
IPR003954
RNA recognition motif domain, eukaryote
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
SM00361
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TIGRFAMs |
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Modification |
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SwissProt |
Q14011
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PhosphoSite |
PhosphoSite-Q14011
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TrEMBL |
Q53XX5
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UniProt Splice Variant |
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Entrez Gene |
1153
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UniGene |
Hs.722274
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RefSeq |
NP_001271
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HUGO |
HGNC:1982
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OMIM |
602649
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CCDS |
CCDS12059
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HPRD |
08375
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IMGT |
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EMBL |
AB451225
AB451348
AC004221
AC004258
AF021336
BC000403
BC000901
BT007210
CH471139
D78134
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GenPept |
AAC04895
AAC51787
AAH00403
AAH00901
AAP35874
BAA11212
BAG70039
BAG70162
EAW69520
EAW69523
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