InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gad2

Summary

InnateDB Protein

IDBP-141189.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gad2

Protein Name

glutamic acid decarboxylase 2

Synonyms

6330404F12Rik; Gad-2; GAD(65); GAD65;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028123

InnateDB Gene

IDBG-141187 (Gad2)

Protein Structure

UniProt Annotation

Function

Catalyzes the production of GABA.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell junction, synapse, presynaptic cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Associated to cytoplasmic vesicles. In neurons, cytosolic leaflet of Golgi membranes and presynaptic clusters (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004351	glutamate decarboxylase activity
GO:0005515	protein binding
GO:0016595	glutamate binding
GO:0016831	carboxy-lyase activity
GO:0030170	pyridoxal phosphate binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006540	glutamate decarboxylation to succinate
GO:0019752	carboxylic acid metabolic process
GO:0042136	neurotransmitter biosynthetic process
GO:0042493	response to drug

Cellular Component

GO:0000139	Golgi membrane
GO:0005829	cytosol
GO:0030054	cell junction
GO:0030424	axon
GO:0030672	synaptic vesicle membrane
GO:0031225	anchored component of membrane
GO:0031410	cytoplasmic vesicle
GO:0042734	presynaptic membrane
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm