InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PGAM2

Summary

InnateDB Protein

IDBP-14140.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGAM2

Protein Name

phosphoglycerate mutase 2 (muscle)

Synonyms

GSD10; PGAM-M; PGAMM;

Species

Homo sapiens

Ensembl Protein

ENSP00000297283

InnateDB Gene

IDBG-14138 (PGAM2)

Protein Structure

UniProt Annotation

Function

Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase) and EC 3.1.3.13 (phosphatase), but with a reduced activity.

Subcellular Localization

Disease Associations

Glycogen storage disease 10 (GSD10) [MIM:261670]: A metabolic disorder characterized by myoglobinuria, increased serum creatine kinase levels, decreased phosphoglycerate mutase activity, myalgia, muscle pain, muscle cramps, exercise intolerance. {ECO:0000269PubMed:10545043, ECO:0000269PubMed:8447317}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

In mammalian tissues there are two types of phosphoglycerate mutase isozymes: type-M in muscles and type-B in other tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004082	bisphosphoglycerate mutase activity
GO:0004083	bisphosphoglycerate 2-phosphatase activity
GO:0004619	phosphoglycerate mutase activity
GO:0005515	protein binding
GO:0016868	intramolecular transferase activity, phosphotransferases
GO:0046538	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
GO:0048037	cofactor binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006941	striated muscle contraction
GO:0007283	spermatogenesis
GO:0010035	response to inorganic substance
GO:0016311	dephosphorylation
GO:0044281	small molecule metabolic process
GO:0046689	response to mercury ion