InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PGAM2

Summary

InnateDB Gene

IDBG-14138.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PGAM2

Gene Name

phosphoglycerate mutase 2 (muscle)

Synonyms

GSD10; PGAM-M; PGAMM

Species

Homo sapiens

Ensembl Gene

ENSG00000164708

Encoded Proteins

IDBP-14140

phosphoglycerate mutase 2 (muscle)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Phosphoglycerate mutase (PGAM) catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. The PGAM is a dimeric enzyme containing, in different tissues, different proportions of a slow-migrating muscle (MM) isozyme, a fast-migrating brain (BB) isozyme, and a hybrid form (MB). This gene encodes muscle-specific PGAM subunit. Mutations in this gene cause muscle phosphoglycerate mutase eficiency, also known as glycogen storage disease X. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:44062727-44065587

Strand

Reverse strand

Band

p13

Transcripts

ENST00000297283

ENSP00000297283

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004082	bisphosphoglycerate mutase activity
GO:0004083	bisphosphoglycerate 2-phosphatase activity
GO:0004619	phosphoglycerate mutase activity
GO:0005515	protein binding
GO:0016868	intramolecular transferase activity, phosphotransferases
GO:0046538	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
GO:0048037	cofactor binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006941	striated muscle contraction
GO:0007283	spermatogenesis
GO:0010035	response to inorganic substance
GO:0016311	dephosphorylation
GO:0044281	small molecule metabolic process
GO:0046689	response to mercury ion

Cellular Component

GO:0005634	nucleus
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020475

View Gene Order

ENSBTAG00000014547

Not yet available

Pathways

NETPATH

REACTOME

REACT_1383

Glycolysis pathway

REACT_1520

Gluconeogenesis pathway

REACT_200783

Myoclonic epilepsy of Lafora pathway

REACT_474

Metabolism of carbohydrates pathway

REACT_111217

Metabolism pathway

REACT_116125

Disease pathway

REACT_723

Glucose metabolism pathway

REACT_200833

Glycogen storage diseases pathway

KEGG

hsa00010

Glycolysis / Gluconeogenesis pathway

hsa00260

Glycine, serine and threonine metabolism pathway

INOH

INOH website

Glycolysis Gluconeogenesis pathway

PID NCI

Cross-References

SwissProt

P15259

TrEMBL

UniProt Splice Variant

Entrez Gene

5224

UniGene

Hs.632642

RefSeq

NM_000290

HUGO

HGNC:8889

OMIM

612931

CCDS

CCDS34624

HPRD

IMGT

EMBL

BC001904 BC073741 J05073 M18172 M55673 M55674

GenPept

AAA60072 AAA60073 AAA64238 AAH01904 AAH73741

RNA Seq Atlas

5224