InnateDB Protein
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IDBP-141492.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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E2f3
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Protein Name
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E2F transcription factor 3
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Synonyms
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E2f3a; E2F3b;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000100012
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InnateDB Gene
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IDBG-141490 (E2f3)
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Protein Structure
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Function |
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC- 3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner.
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Subcellular Localization |
Nucleus.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated |
Total |
4
[view]
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Protein-Protein |
4
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
26 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1096340
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InterPro |
IPR003316
Transcription factor E2F/dimerisation partner (TDP)
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PFAM |
PF02319
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O35261
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q3UZJ0
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UniProt Splice Variant |
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Entrez Gene |
13557
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UniGene |
Mm.472655
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RefSeq |
NP_034223
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MGI ID |
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MGI Symbol |
E2f3
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OMIM |
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CCDS |
CCDS26413
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HPRD |
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IMGT |
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EMBL |
AF015948
AK133828
AL513025
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GenPept |
AAB71671
BAE21867
CAI24679
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