Version 5.4
Mus musculus Gene: E2f3
Summary
InnateDB Gene IDBG-141490.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol E2f3
Gene Name E2F transcription factor 3
Synonyms E2f3a; E2F3b
Species Mus musculus
Ensembl Gene ENSMUSG00000016477
Encoded Proteins
IDBP-141492
E2F transcription factor 3
IDBP-536464
E2F transcription factor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112242:
This gene encodes a member of a small family of transcriptional factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate expression of cell-cycle genes. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:29906575-29985668
Strand Reverse strand
Band A3.2
Transcripts
ENSMUST00000102948 ENSMUSP00000100012
ENSMUST00000146092 ENSMUSP00000114152
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001047 core promoter binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007049 cell cycle
GO:0008284 positive regulation of cell proliferation
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000112242
View Gene Order
ENSBTAG00000021045
Not yet available
Pathways
NETPATH
REACTOME
REACT_249770
Cell Cycle, Mitotic pathway
REACT_260005
G1 Phase pathway
REACT_227891
G2 Phase pathway
REACT_232628
DNA Replication pathway
REACT_188804
Cell Cycle pathway
REACT_258573
Cyclin D associated events in G1 pathway
REACT_259974
CDC6 association with the ORC:origin complex pathway
REACT_255479
Regulation of DNA replication pathway
REACT_245528
M/G1 Transition pathway
REACT_246508
Mitotic G2-G2/M phases pathway
REACT_262002
Association of licensing factors with the pre-replicative complex pathway
REACT_250573
Mitotic G1-G1/S phases pathway
REACT_235483
DNA Replication Pre-Initiation pathway
REACT_230841
Assembly of the pre-replicative complex pathway
KEGG
mmu05219
Bladder cancer pathway
mmu05218
Melanoma pathway
mmu04110
Cell cycle pathway
mmu05214
Glioma pathway
mmu05222
Small cell lung cancer pathway
mmu05215
Prostate cancer pathway
mmu05220
Chronic myeloid leukemia pathway
mmu05223
Non-small cell lung cancer pathway
mmu05212
Pancreatic cancer pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1181
Association of licensing factors with the pre-replicative complex pathway
REACT_1707
CDC6 association with the ORC:origin complex pathway
REACT_2243
Assembly of the pre-replicative complex pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_1915
G2 Phase pathway
REACT_118568
Pre-NOTCH Transcription and Translation pathway
REACT_383
DNA Replication pathway
REACT_1590
G1 Phase pathway
REACT_120956
Cellular responses to stress pathway
REACT_169325
Oncogene Induced Senescence pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_111102
Signal Transduction pathway
REACT_115566
Cell Cycle pathway
REACT_169274
Cellular Senescence pathway
REACT_299
Signaling by NOTCH pathway
REACT_1725
M/G1 Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_829
Regulation of DNA replication pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
KEGG
hsa05223
Non-small cell lung cancer pathway
hsa04110
Cell cycle pathway
hsa05218
Melanoma pathway
hsa05219
Bladder cancer pathway
hsa05214
Glioma pathway
hsa05222
Small cell lung cancer pathway
hsa05215
Prostate cancer pathway
hsa05220
Chronic myeloid leukemia pathway
hsa05212
Pancreatic cancer pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
myc_activpathway
Validated targets of C-MYC transcriptional activation
e2f_pathway
E2F transcription factor network
Cross-References
SwissProt O35261
TrEMBL I7HFT6 Q3UZJ0
UniProt Splice Variant
Entrez Gene 13557
UniGene Mm.268356 Mm.455450 Mm.472655
RefSeq NM_001289920 NM_010093 XM_006516542
OMIM
CCDS CCDS26413
HPRD
IMGT
MGI ID MGI:1096340
MGI Symbol E2f3
EMBL AF015948 AK133828 AL513025
GenPept AAB71671 BAE21867 CAI24678 CAI24679
RNA Seq Atlas 13557

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca