InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Agap3

Summary

InnateDB Protein

IDBP-141500.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Agap3

Protein Name

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000024123

InnateDB Gene

IDBG-141498 (Agap3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding
GO:0031593	polyubiquitin binding

Biological Process

GO:0000060	protein import into nucleus, translocation
GO:0006184	GTP catabolic process
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0030578	PML body organization
GO:0032312	regulation of ARF GTPase activity
GO:0034614	cellular response to reactive oxygen species
GO:0034644	cellular response to UV
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0016020	membrane
GO:0016605	PML body
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

MGI:2183446

InterPro

IPR001164 Arf GTPase activating protein
IPR001806 Small GTPase superfamily
IPR001849 Pleckstrin homology domain
IPR002110 Ankyrin repeat
IPR003579 Small GTPase superfamily, Rab type
IPR013684 Mitochondrial Rho-like
IPR020683 Ankyrin repeat-containing domain
IPR020849 Small GTPase superfamily, Ras type
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM