Version 5.4
Mus musculus Protein: Themis
Summary
InnateDB Protein IDBP-141617.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Themis
Protein Name thymocyte selection associated
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000060129
InnateDB Gene IDBG-141613 (Themis)
Protein Structure
UniProt Annotation
Function Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk. {ECO:0000269PubMed:19597497, ECO:0000269PubMed:19597498, ECO:0000269PubMed:19597499, ECO:0000269PubMed:19620281, ECO:0000269PubMed:19805304}.
Subcellular Localization Cytoplasm. Nucleus.
Disease Associations
Tissue Specificity Expressed in the thymus and to a lesser extent in the spleen but not detectable in non-lymphoid tissues. Highly expressed in thymocytes between the pre-T-cell antigen receptor (pre-TCR) and positive-selection checkpoints and expressed at low level in mature T-cells (at protein level). {ECO:0000269PubMed:19597497, ECO:0000269PubMed:19597498, ECO:0000269PubMed:19597499, ECO:0000269PubMed:19805304}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0043368 positive T cell selection
GO:0043383 negative T cell selection
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0008180 COP9 signalosome
Protein Structure and Domains
PDB ID MGI:2443552
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BGW0
PhosphoSite PhosphoSite-Q8BGW0
TrEMBL
UniProt Splice Variant
Entrez Gene 210757
UniGene Mm.123021
RefSeq NP_848781
MGI ID
MGI Symbol Themis
OMIM
CCDS CCDS23758
HPRD
IMGT
EMBL AB509340 AK040594 AK041386 AK041562 AK041622 AK088136 AK089077 AK138701 AK169558 BC125486 BC125488 CH466540
GenPept AAI25487 AAI25489 BAC30638 BAC30927 BAC30986 BAC31008 BAC40167 BAC40738 BAE23752 BAE41228 BAH79575 EDL04825

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca