Version 5.4
Mus musculus Gene: Themis
Summary
InnateDB Gene IDBG-141613.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Themis
Gene Name thymocyte selection associated
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000049109
Encoded Proteins
IDBP-141615
thymocyte selection associated
IDBP-141617
thymocyte selection associated
IDBP-270719
thymocyte selection associated
IDBP-538210
thymocyte selection associated
IDBP-540337
thymocyte selection associated
IDBP-534078
thymocyte selection associated
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172673:
This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:28668360-28883818
Strand Forward strand
Band A4
Transcripts
ENSMUST00000060409 ENSMUSP00000055315
ENSMUST00000056097 ENSMUSP00000060129
ENSMUST00000105516 ENSMUSP00000101155
ENSMUST00000162343
ENSMUST00000159927 ENSMUSP00000123919
ENSMUST00000162202 ENSMUSP00000124451
ENSMUST00000161345 ENSMUSP00000123894
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0043368 positive T cell selection
GO:0043383 negative T cell selection
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0008180 COP9 signalosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000172673
View Gene Order
ENSBTAG00000015615
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.123021
RefSeq NM_178666 XM_006512642 XM_006512643
OMIM
CCDS CCDS23758
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca