InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mastl

Summary

InnateDB Protein

IDBP-141641.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mastl

Protein Name

microtubule associated serine/threonine kinase-like

Synonyms

2700091H24Rik; C88295; GW; GWL; MAST-L; THC2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028119

InnateDB Gene

IDBG-141639 (Mastl)

Protein Structure

UniProt Annotation

Function

Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0051721	protein phosphatase 2A binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0006974	cellular response to DNA damage stimulus
GO:0007067	mitotic nuclear division
GO:0034048	negative regulation of protein phosphatase type 2A activity
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0032154	cleavage furrow

Protein Structure and Domains

PDB ID

MGI:1914371

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt