Version 5.4
Mus musculus Protein: Sec14l2
Summary
InnateDB Protein IDBP-141674.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sec14l2
Protein Name SEC14-like 2 (S. cerevisiae)
Synonyms 1300013M05Rik; Spf; TAP;
Species Mus musculus
Ensembl Protein ENSMUSP00000003681
InnateDB Gene IDBG-141672 (Sec14l2)
Protein Structure
UniProt Annotation
Function Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Cytoplasmic in absence of alpha-tocopherol, and nuclear in presence of alpha-tocopherol. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0008289 lipid binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006810 transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1915065
InterPro IPR001071 Cellular retinaldehyde binding/alpha-tocopherol transport
IPR001251 CRAL-TRIO domain
IPR009038 GOLD
IPR011074 CRAL/TRIO, N-terminal domain
PFAM PF00650
PF13716
PF01105
PF13897
PF03765
PRINTS PR00180
PIRSF
SMART SM00516
SM01100
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q99J08
PhosphoSite PhosphoSite-Q99J08
TrEMBL
UniProt Splice Variant
Entrez Gene 67815
UniGene Mm.392514
RefSeq NP_653103
MGI ID
MGI Symbol Sec14l2
OMIM
CCDS CCDS24377
HPRD
IMGT
EMBL BC005759
GenPept AAH05759

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca