InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mtbp

Summary

InnateDB Protein

IDBP-141713.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mtbp

Protein Name

Mdm2, transformed 3T3 cell double minute p53 binding protein

Synonyms

AI429604; MDM2BP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022998

InnateDB Gene

IDBG-141711 (Mtbp)

Protein Structure

UniProt Annotation

Function

May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells. {ECO:0000269PubMed:10906133, ECO:0000269PubMed:15632057}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in small intestine and spleen at low levels, in the ovary at intermediate levels and in the testis and thymus at high levels. {ECO:0000269PubMed:10906133}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007050	cell cycle arrest
GO:0007089	traversing start control point of mitotic cell cycle
GO:0008285	negative regulation of cell proliferation
GO:0034501	protein localization to kinetochore
GO:0071174	mitotic spindle checkpoint