Version 5.4
| Mus musculus Protein: Cacna2d3 | |||||||
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| Summary | |||||||
| InnateDB Protein | IDBP-141725.6 | ||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||
| Gene Symbol | Cacna2d3 | ||||||
| Protein Name | calcium channel, voltage-dependent, alpha2/delta subunit 3 | ||||||
| Synonyms | Cacnad3; | ||||||
| Species | Mus musculus | ||||||
| Ensembl Protein | ENSMUSP00000022567 | ||||||
| InnateDB Gene | IDBG-141723 (Cacna2d3) | ||||||
| Protein Structure |
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| UniProt Annotation | |||||||
| Function | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) but not T-type (CACNA1G). {ECO:0000269PubMed:10200414, ECO:0000269PubMed:9880589}. | ||||||
| Subcellular Localization | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. | ||||||
| Disease Associations | |||||||
| Tissue Specificity | Brain-specific. Predominantly expressed in the caudate putamen, entorhinal complex, hippocampus and cortex. {ECO:0000269PubMed:11687876, ECO:0000269PubMed:9880589}. | ||||||
| Comments | |||||||
| Interactions | |||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||
| PDB ID | MGI:1338890 | ||||||
| InterPro |
IPR002035
von Willebrand factor, type A IPR004010 Cache domain IPR013608 VWA N-terminal |
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| PFAM |
PF00092
PF02743 PF08269 PF08399 |
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| PRINTS | |||||||
| PIRSF | |||||||
| SMART |
SM00327
SM01049 |
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| TIGRFAMs | |||||||
| Post-translational Modifications | |||||||
| Modification | |||||||
| Cross-References | |||||||
| SwissProt | Q9Z1L5 | ||||||
| PhosphoSite | PhosphoSite- | ||||||
| TrEMBL | |||||||
| UniProt Splice Variant | |||||||
| Entrez Gene | 12294 | ||||||
| UniGene | Mm.488024 | ||||||
| RefSeq | NP_033915 | ||||||
| MGI ID | |||||||
| MGI Symbol | Cacna2d3 | ||||||
| OMIM | |||||||
| CCDS | |||||||
| HPRD | |||||||
| IMGT | |||||||
| EMBL | AJ010949 | ||||||
| GenPept | CAA09423 | ||||||