InnateDB Protein
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IDBP-141728.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ndfip1
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Protein Name
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Nedd4 family interacting protein 1
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Synonyms
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0610010M22Rik; N4wbp5;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000025293
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InnateDB Gene
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IDBG-141726 (Ndfip1)
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Protein Structure
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Function |
Activates HECT domain-containing several E3 ubiquitin- protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cells-mediated inflammation by activating ITCH and thus controlling JUNB degradation. In cortical neurons, mediates the ubiquitination of SLC11A2/DMT1 by NEDD4L, leading to down-regulation of the divalent metal transporter and protection of the cells from cobalt and iron toxicity (By similarity). Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1- to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000269PubMed:11748237, ECO:0000269PubMed:16822981, ECO:0000269PubMed:18819914}. Secreted {ECO:0000250}. Note=Detected in exosomes and secreted via the exosomal pathway. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Hardly detectable in resting T-cells; up-regulated in T-cells in response to activation. {ECO:0000269PubMed:11748237, ECO:0000269PubMed:17137798}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
12
[view]
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Protein-Protein |
12
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
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Biological Process |
GO:0002761
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regulation of myeloid leukocyte differentiation
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GO:0002829
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negative regulation of type 2 immune response
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GO:0006879
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cellular iron ion homeostasis
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GO:0007165
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signal transduction
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GO:0010629
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negative regulation of gene expression
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GO:0031398
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positive regulation of protein ubiquitination
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GO:0032410
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negative regulation of transporter activity
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GO:0032713
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negative regulation of interleukin-4 production
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GO:0042130
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negative regulation of T cell proliferation
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GO:0043123
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positive regulation of I-kappaB kinase/NF-kappaB signaling
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GO:0043162
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ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
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GO:0045619
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regulation of lymphocyte differentiation
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GO:0045732
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positive regulation of protein catabolic process
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GO:0048294
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negative regulation of isotype switching to IgE isotypes
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GO:0048302
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regulation of isotype switching to IgG isotypes
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GO:0050728
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negative regulation of inflammatory response
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GO:0051224
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negative regulation of protein transport
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Cellular Component |
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PDB ID |
MGI:1929601
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InterPro |
IPR019325
NEDD4/BSD2
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PFAM |
PF10176
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8R0W6
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PhosphoSite |
PhosphoSite-Q8R0W6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
65113
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UniGene |
Mm.102496
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RefSeq |
NP_075372
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MGI ID |
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MGI Symbol |
Ndfip1
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OMIM |
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CCDS |
CCDS37789
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HPRD |
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IMGT |
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EMBL |
AF220209
AK050560
BC026372
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GenPept |
AAG44248
AAH26372
BAC34324
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