Version 5.4
Mus musculus Gene: Ndfip1
Summary
InnateDB Gene IDBG-141726.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ndfip1
Gene Name Nedd4 family interacting protein 1
Synonyms 0610010M22Rik; N4wbp5
Species Mus musculus
Ensembl Gene ENSMUSG00000024425
Encoded Proteins
IDBP-141728
Nedd4 family interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131507:
The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:38418975-38464399
Strand Forward strand
Band B3
Transcripts
ENSMUST00000025293 ENSMUSP00000025293
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0050699 WW domain binding
Biological Process
GO:0002761 regulation of myeloid leukocyte differentiation
GO:0002829 negative regulation of type 2 immune response
GO:0006879 cellular iron ion homeostasis
GO:0007165 signal transduction
GO:0010629 negative regulation of gene expression
GO:0031398 positive regulation of protein ubiquitination
GO:0032410 negative regulation of transporter activity
GO:0032713 negative regulation of interleukin-4 production
GO:0042130 negative regulation of T cell proliferation
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0045619 regulation of lymphocyte differentiation
GO:0045732 positive regulation of protein catabolic process
GO:0048294 negative regulation of isotype switching to IgE isotypes
GO:0048302 regulation of isotype switching to IgG isotypes
GO:0050728 negative regulation of inflammatory response
GO:0051224 negative regulation of protein transport
Cellular Component
GO:0005576 extracellular region
GO:0005794 Golgi apparatus
GO:0005938 cell cortex
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000131507
View Gene Order
ENSBTAG00000047747
Not yet available
Cross-References
SwissProt Q8R0W6
TrEMBL
UniProt Splice Variant
Entrez Gene 65113
UniGene Mm.102496
RefSeq NM_022996 XM_006526149
OMIM
CCDS CCDS37789
HPRD
IMGT
MGI ID MGI:1929601
MGI Symbol Ndfip1
EMBL AF220209 AK050560 BC026372
GenPept AAG44248 AAH26372 BAC34324
RNA Seq Atlas 65113

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca