InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: KLB

Summary

InnateDB Protein

IDBP-14186.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KLB

Protein Name

klotho beta

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000257408

InnateDB Gene

IDBG-14182 (KLB)

Protein Structure

UniProt Annotation

Function

Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0005515	protein binding
GO:0017134	fibroblast growth factor binding

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway