InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arhgap26

Summary

InnateDB Protein

IDBP-141862.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arhgap26

Protein Name

Rho GTPase activating protein 26

Synonyms

1810044B20Rik; 2610010G17Rik; 4933432P15Rik; AI853435; mKIAA0621;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095200

InnateDB Gene

IDBG-141860 (Arhgap26)

Protein Structure

UniProt Annotation

Function

GTPase-activating protein for RHOA and CDC42. {ECO:0000250}.

Subcellular Localization

Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with actin stress fibers and cortical actin structures. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0008093	cytoskeletal adaptor activity
GO:0017124	SH3 domain binding

Biological Process

GO:0007165	signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0046847	filopodium assembly

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005925	focal adhesion

Protein Structure and Domains

PDB ID

MGI:1918552

InterPro

IPR000198 Rho GTPase-activating protein domain
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein
IPR011511 Variant SH3 domain
IPR013606 IRSp53/MIM homology domain (IMD)

PFAM

PF00620
PF00018
PF14604
PF00169
PF07653
PF08397

PRINTS

PR00452

PIRSF

SMART

SM00324
SM00326
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt