InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITPR1

Summary

InnateDB Protein

IDBP-14193.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITPR1

Protein Name

inositol 1,4,5-trisphosphate receptor, type 1

Synonyms

ACV; CLA4; INSP3R1; IP3R; IP3R1; PPP1R94; SCA15; SCA16; SCA29;

Species

Homo sapiens

Ensembl Protein

ENSP00000306253

InnateDB Gene

IDBG-14187 (ITPR1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 46 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	46 [view]
Protein-Protein	46 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005218	intracellular ligand-gated calcium channel activity
GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0015085	calcium ion transmembrane transporter activity
GO:0035091	phosphatidylinositol binding

Biological Process

GO:0001666	response to hypoxia
GO:0006112	energy reserve metabolic process
GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007165	signal transduction
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007202	activation of phospholipase C activity
GO:0007596	blood coagulation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009791	post-embryonic development
GO:0030168	platelet activation
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038096	Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048016	inositol phosphate-mediated signaling
GO:0050796	regulation of insulin secretion
GO:0050882	voluntary musculoskeletal movement
GO:0051209	release of sequestered calcium ion into cytosol
GO:0055085	transmembrane transport
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005955	calcineurin complex
GO:0014069	postsynaptic density
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016529	sarcoplasmic reticulum
GO:0031088	platelet dense granule membrane
GO:0031094	platelet dense tubular network
GO:0031095	platelet dense tubular network membrane
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000493 Inositol 1,4,5-trisphosphate-binding protein receptor
IPR000699 RIH (RyR and IP3R Homology) domain
IPR005821 Ion transport domain
IPR013662 RyR/IP3R Homology associated domain
IPR014821 Inositol 1,4,5-trisphosphate/ryanodine receptor
IPR016093 MIR motif

PFAM

PF01365
PF00520
PF08454
PF08709
PF02815

PRINTS

PR00779

PIRSF

SMART

SM00472

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt