InnateDB Protein
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IDBP-142126.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Derl1
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Protein Name
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Der1-like domain family, member 1
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Synonyms
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1110021N07Rik; AI195141; AW551338; Derlin-1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000022993
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InnateDB Gene
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IDBG-142124 (Derl1)
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Protein Structure
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Function |
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Widely expressed, with lowest levels in brain and heart. {ECO:0000269PubMed:16186509}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
|
Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
38 [view]
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Molecular Function |
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Biological Process |
GO:0006986
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response to unfolded protein
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GO:0030433
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ER-associated ubiquitin-dependent protein catabolic process
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GO:0030968
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endoplasmic reticulum unfolded protein response
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GO:0030970
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retrograde protein transport, ER to cytosol
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GO:0034620
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cellular response to unfolded protein
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Cellular Component |
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PDB ID |
MGI:1915069
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InterPro |
IPR007599
Derlin
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PFAM |
PF04511
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99J56
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PhosphoSite |
PhosphoSite-Q99J56
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
67819
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UniGene |
Mm.398001
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RefSeq |
NP_077169
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MGI ID |
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MGI Symbol |
Derl1
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OMIM |
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CCDS |
CCDS27484
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HPRD |
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IMGT |
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EMBL |
AK007435
AK043420
AK075631
AK152197
AK152901
BC003454
BC085490
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GenPept |
AAH03454
AAH85490
BAB25036
BAC31545
BAC35868
BAE31026
BAE31582
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