InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Derl1

Summary

InnateDB Gene

IDBG-142124.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Derl1

Gene Name

Der1-like domain family, member 1

Synonyms

1110021N07Rik; AI195141; AW551338; Derlin-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022365

Encoded Proteins

IDBP-142126

Der1-like domain family, member 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000136986:
The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:57869502-57892418

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022993

ENSMUSP00000022993

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042288	MHC class I protein binding

Biological Process

GO:0006986	response to unfolded protein
GO:0030433	ER-associated ubiquitin-dependent protein catabolic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0030970	retrograde protein transport, ER to cytosol
GO:0034620	cellular response to unfolded protein

Cellular Component

GO:0000836	Hrd1p ubiquitin ligase complex
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005783	endoplasmic reticulum
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030176	integral component of endoplasmic reticulum membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000136986

View Gene Order

ENSBTAG00000020693

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu05014

Amyotrophic lateral sclerosis (ALS) pathway

mmu04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa05014

Amyotrophic lateral sclerosis (ALS) pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

Q99J56

TrEMBL

UniProt Splice Variant

Entrez Gene

67819

UniGene

Mm.289387 Mm.398001

RefSeq

NM_024207

OMIM

CCDS

CCDS27484

HPRD

IMGT

MGI ID

MGI:1915069

MGI Symbol

Derl1

EMBL

AK007435 AK043420 AK075631 AK152197 AK152901 BC003454 BC085490

GenPept

AAH03454 AAH85490 BAB25036 BAC31545 BAC35868 BAE31026 BAE31582

RNA Seq Atlas

67819