InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Epha1

Summary

InnateDB Protein

IDBP-142166.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epha1

Protein Name

Eph receptor A1

Synonyms

5730453L17Rik; AL033318; Eph; Esk;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073099

InnateDB Gene

IDBG-142164 (Epha1)

Protein Structure

UniProt Annotation

Function

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. {ECO:0000269PubMed:18802966}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Preferentially expressed in epithelial cells including skin, kidney, liver and thymus. {ECO:0000269PubMed:11519828, ECO:0000269PubMed:18802966}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005005	transmembrane-ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0001525	angiogenesis
GO:0001954	positive regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0007166	cell surface receptor signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030335	positive regulation of cell migration
GO:0030336	negative regulation of cell migration
GO:0032314	regulation of Rac GTPase activity
GO:0032862	activation of Rho GTPase activity
GO:0034446	substrate adhesion-dependent cell spreading
GO:0045766	positive regulation of angiogenesis
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway
GO:0051496	positive regulation of stress fiber assembly

Cellular Component

GO:0005887

integral component of plasma membrane

Protein Structure and Domains

PDB ID

MGI:107381

InterPro

IPR000719 Protein kinase domain
IPR001090 Ephrin receptor ligand binding domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001660 Sterile alpha motif domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR003961 Fibronectin, type III
IPR008979 Galactose-binding domain-like
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011009 Protein kinase-like domain
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR016257 Ephrin receptor type-A /type-B
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR021129 Sterile alpha motif, type 1

PFAM