InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Epha1

Summary

InnateDB Gene

IDBG-142164.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epha1

Gene Name

Eph receptor A1

Synonyms

5730453L17Rik; AL033318; Eph; Esk

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029859

Encoded Proteins

IDBP-142166

Eph receptor A1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000146904:
This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene is expressed in some human cancer cell lines and has been implicated in carcinogenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:42358487-42373268

Strand

Reverse strand

Band

B2.1

Transcripts

ENSMUST00000073387

ENSMUSP00000073099

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	4 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005003	ephrin receptor activity
GO:0005005	transmembrane-ephrin receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0001525	angiogenesis
GO:0001954	positive regulation of cell-matrix adhesion
GO:0006468	protein phosphorylation
GO:0006469	negative regulation of protein kinase activity
GO:0007166	cell surface receptor signaling pathway
GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
GO:0008284	positive regulation of cell proliferation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0030335	positive regulation of cell migration
GO:0030336	negative regulation of cell migration
GO:0032314	regulation of Rac GTPase activity
GO:0032862	activation of Rho GTPase activity
GO:0034446	substrate adhesion-dependent cell spreading
GO:0045766	positive regulation of angiogenesis
GO:0046777	protein autophosphorylation
GO:0048013	ephrin receptor signaling pathway
GO:0051496	positive regulation of stress fiber assembly