InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Epor

Summary

InnateDB Protein

IDBP-142380.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Epor

Protein Name

erythropoietin receptor

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006397

InnateDB Gene

IDBG-142378 (Epor)

Protein Structure

UniProt Annotation

Function

Receptor for erythropoietin. Mediates erythropoietin- induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. {ECO:0000269PubMed:8382775, ECO:0000269PubMed:8617735}.

Subcellular Localization

Isoform EPOR-F: Cell membrane; Single-pass type I membrane protein.Isoform EPOR-S: Secreted.

Disease Associations

Tissue Specificity

Expressed in relatively mature erythroid progenitor cells and in EPO-responsive erythroleukemia cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004900	erythropoietin receptor activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0003007	heart morphogenesis
GO:0007165	signal transduction
GO:0007420	brain development
GO:0007507	heart development
GO:0016032	viral process
GO:0038162	erythropoietin-mediated signaling pathway
GO:0046697	decidualization
GO:0055008	cardiac muscle tissue morphogenesis
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060979	vasculogenesis involved in coronary vascular morphogenesis
GO:0061032	visceral serous pericardium development