InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NRXN3

Summary

InnateDB Protein

IDBP-14244.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRXN3

Protein Name

neurexin 3

Synonyms

C14orf60;

Species

Homo sapiens

Ensembl Protein

ENSP00000338349

InnateDB Gene

IDBG-14238 (NRXN3)

Protein Structure

UniProt Annotation

Function

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in the blood vessel walls (at protein level). Highly expressed in brain, lung, and pancreas; a lower level of expression is detectable in heart, placenta, liver, and kidney, whereas no expression can be observed in skeletal muscle. Isoform 4a is heart-specific. {ECO:0000269PubMed:12379233, ECO:0000269PubMed:19926856}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0050839	cell adhesion molecule binding
GO:0097109	neuroligin family protein binding

Biological Process

GO:0007158	neuron cell-cell adhesion
GO:0007411	axon guidance
GO:0007612	learning
GO:0030534	adult behavior
GO:0035176	social behavior
GO:0051965	positive regulation of synapse assembly
GO:0071625	vocalization behavior
GO:0090129	positive regulation of synapse maturation