InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NRXN3

Summary

InnateDB Gene

IDBG-14238.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NRXN3

Gene Name

neurexin 3

Synonyms

C14orf60

Species

Homo sapiens

Ensembl Gene

ENSG00000021645

Encoded Proteins

IDBP-14244

neurexin 3

IDBP-14246

neurexin 3

IDBP-375038

neurexin 3

IDBP-600494

neurexin 3

IDBP-593596

neurexin 3

IDBP-586554

neurexin 3

IDBP-596813

neurexin 3

IDBP-598818

neurexin 3

IDBP-598655

neurexin 3

IDBP-601196

neurexin 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of a family of proteins that function in the nervous system as receptors and cell adhesion molecules. Extensive alternative splicing and the use of alternative promoters results in multiple transcript variants and protein isoforms for this gene, but the full-length nature of many of these variants has not been determined. Transcripts that initiate from an upstream promoter encode alpha isoforms, which contain epidermal growth factor-like (EGF-like) sequences and laminin G domains. Transcripts initiating from the downstream promoter encode beta isoforms, which lack EGF-like sequences. Genetic variation at this locus has been associated with a range of behavioral phenotypes, including alcohol dependence and autism spectrum disorder. [provided by RefSeq, Dec 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:78242391-79868290

Strand

Forward strand

Band

q24.3

Transcripts

ENST00000335750	ENSP00000338349
ENST00000281127	ENSP00000281127
ENST00000428277	ENSP00000394426
ENST00000554738	ENSP00000450683
ENST00000556088
ENST00000553363	ENSP00000451754
ENST00000553631	ENSP00000451947
ENST00000554719	ENSP00000451648
ENST00000556496
ENST00000557081	ENSP00000450462
ENST00000557594	ENSP00000451672
ENST00000555387	ENSP00000451393
ENST00000555073
ENST00000553803
ENST00000556003

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005246	calcium channel regulator activity
GO:0005515	protein binding
GO:0046872	metal ion binding
GO:0050839	cell adhesion molecule binding
GO:0097109	neuroligin family protein binding

Biological Process

GO:0001525	angiogenesis
GO:0007158	neuron cell-cell adhesion
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007411	axon guidance
GO:0007416	synapse assembly
GO:0007612	learning
GO:0030534	adult behavior
GO:0035176	social behavior
GO:0051965	positive regulation of synapse assembly
GO:0071625	vocalization behavior
GO:0090129	positive regulation of synapse maturation

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000066392

View Gene Order

Pathways

NETPATH

REACTOME

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

INOH

PID NCI

Cross-References

SwissProt

Q9Y4C0

TrEMBL

G3V247 G3V4R9

UniProt Splice Variant

Entrez Gene

9369

UniGene

Hs.368307 Hs.627999 Hs.715668

RefSeq

NM_004796 NM_001105250 NM_001272020 NM_138970

HUGO

HGNC:8010

OMIM

600567

CCDS

CCDS9870 CCDS45145 CCDS61515 CCDS9871

HPRD

08989

IMGT

EMBL

AB018286 AC007056 AC007058 AC008045 AC008056 AC009396 AC011440 AC012099 AC018514 AC022469 AC026888 AF099810 AF123462 AJ316284 BC152457 CH471061

GenPept

AAC68909 AAD13621 AAF09143 AAF15058 AAF21147 AAF28465 AAF61277 AAF87841 AAI52458 BAA34463 CAC87720 EAW81316

RNA Seq Atlas

9369