InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Slc7a11

Summary

InnateDB Protein

IDBP-142532.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc7a11

Protein Name

solute carrier family 7 (cationic amino acid transporter, y+ system), member 11

Synonyms

9930009M05Rik; AI451155; sut; xCT;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029297

InnateDB Gene

IDBG-142530 (Slc7a11)

Protein Structure

UniProt Annotation

Function

Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate.

Subcellular Localization

Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015171	amino acid transmembrane transporter activity

Biological Process

GO:0003333	amino acid transmembrane transport
GO:0006810	transport
GO:0006865	amino acid transport
GO:0006979	response to oxidative stress
GO:0007420	brain development
GO:0009636	response to toxic substance
GO:0035094	response to nicotine
GO:0055085	transmembrane transport
GO:0070306	lens fiber cell differentiation
GO:0070527	platelet aggregation

Cellular Component

GO:0005791	rough endoplasmic reticulum
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle