InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Slc7a11

Summary

InnateDB Gene

IDBG-142530.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Slc7a11

Gene Name

solute carrier family 7 (cationic amino acid transporter, y+ system), member 11

Synonyms

9930009M05Rik; AI451155; sut; xCT

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027737

Encoded Proteins

IDBP-142532

solute carrier family 7 (cationic amino acid transporter, y+ system), member 11

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151012:
This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:50364936-50443613

Strand

Reverse strand

Band

Transcripts

ENSMUST00000029297	ENSMUSP00000029297
ENSMUST00000142932

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0015171	amino acid transmembrane transporter activity

Biological Process

GO:0003333	amino acid transmembrane transport
GO:0006810	transport
GO:0006865	amino acid transport
GO:0006979	response to oxidative stress
GO:0007420	brain development
GO:0009636	response to toxic substance
GO:0035094	response to nicotine
GO:0055085	transmembrane transport
GO:0070306	lens fiber cell differentiation
GO:0070527	platelet aggregation

Cellular Component

GO:0005791	rough endoplasmic reticulum
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle