InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cacna1b

Summary

InnateDB Protein

IDBP-142649.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Cacna1b

Protein Name

calcium channel, voltage-dependent, N type, alpha 1B subunit

Synonyms

alpha(1B); AW050276; AW060892; AW822256; Cav2.2; Cchn1a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000063236

InnateDB Gene

IDBG-142643 (Cacna1b)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008331	high voltage-gated calcium channel activity

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007269	neurotransmitter secretion
GO:0007626	locomotory behavior
GO:0008016	regulation of heart contraction
GO:0008217	regulation of blood pressure
GO:0034765	regulation of ion transmembrane transport
GO:0048265	response to pain
GO:0051924	regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0005891	voltage-gated calcium channel complex
GO:0016020	membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:88296

InterPro

IPR002048 EF-hand domain
IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
IPR003915 Polycystic kidney disease type 2 protein
IPR005447 Voltage-dependent calcium channel, N-type, alpha-1 subunit
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain

PFAM

PF00036
PF13202
PF13405
PF00520
PF08016
PF08763

PRINTS

PR00167
PR01433
PR01631

PIRSF

SMART

SM00054
SM01062

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt