InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cacna1b

Summary

InnateDB Protein

IDBP-142651.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cacna1b

Protein Name

calcium channel, voltage-dependent, N type, alpha 1B subunit

Synonyms

alpha(1B); AW050276; AW060892; AW822256; Cav2.2; Cchn1a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037416

InnateDB Gene

IDBG-142643 (Cacna1b)

Protein Structure

UniProt Annotation

Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin- IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Widespread expression throughout the brain. Highest levels in pyramidal cell layers C1, C2 and C3 of the hippocampus, in the dentate gyrus, in the cortex layers 2 et 4, in the subiculum and the habenula.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008331	high voltage-gated calcium channel activity

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007269	neurotransmitter secretion
GO:0007626	locomotory behavior
GO:0008016	regulation of heart contraction
GO:0008217	regulation of blood pressure
GO:0034765	regulation of ion transmembrane transport
GO:0048265	response to pain
GO:0051924	regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0005891	voltage-gated calcium channel complex
GO:0016020	membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:88296

InterPro

IPR002048 EF-hand domain
IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
IPR003915 Polycystic kidney disease type 2 protein
IPR005447 Voltage-dependent calcium channel, N-type, alpha-1 subunit
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain

PFAM

PF00036
PF13202
PF13405
PF00520
PF08016
PF08763

PRINTS

PR00167
PR01433
PR01631

PIRSF

SMART

SM00054
SM01062

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt