InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tkt

Summary

InnateDB Protein

IDBP-142742.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tkt

Protein Name

transketolase

Synonyms

p68;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022529

InnateDB Gene

IDBG-142740 (Tkt)

Protein Structure

UniProt Annotation

Function

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004802	transketolase activity
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding
GO:0048037	cofactor binding

Biological Process

GO:0008152	metabolic process
GO:0040008	regulation of growth
GO:0046166	glyceraldehyde-3-phosphate biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:105992

InterPro

IPR001017 Dehydrogenase, E1 component
IPR005474 Transketolase, N-terminal
IPR005475 Transketolase-like, pyrimidine-binding domain
IPR005476 Transketolase, C-terminal
IPR009014 Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II
IPR029061 Thiamin diphosphate-binding fold

PFAM

PF00676
PF00456
PF02779
PF02780

PRINTS

PIRSF

SMART

SM00861

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P40142