Version 5.4
Mus musculus Gene: Tkt
Summary
InnateDB Gene IDBG-142740.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tkt
Gene Name transketolase
Synonyms p68
Species Mus musculus
Ensembl Gene ENSMUSG00000021957
Encoded Proteins
IDBP-142742
transketolase
IDBP-537027
transketolase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme that binds magnesium and thiamine pyrophosphate and catalyzes the transfer of sugar phosphates to an aldose acceptor. This enzyme is a key component of the pentose phosphate pathway during glycolysis. It is significantly expressed in the cornea and may be involved in the cellular response against oxidative stress. Haploinsufficiency of this gene leads to decreased growth and reduction of adipose tissue. [provided by RefSeq, Dec 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:30548359-30574722
Strand Forward strand
Band B
Transcripts
ENSMUST00000022529 ENSMUSP00000022529
ENSMUST00000160274
ENSMUST00000160189
ENSMUST00000162356 ENSMUSP00000124485
ENSMUST00000160406
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004802 transketolase activity
GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0048037 cofactor binding
Biological Process
GO:0008152 metabolic process
GO:0040008 regulation of growth
GO:0046166 glyceraldehyde-3-phosphate biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163931
View Gene Order
ENSBTAG00000003758
Not yet available
Pathways
NETPATH
REACTOME
REACT_239811
Insulin effects increased synthesis of Xylulose-5-Phosphate pathway
REACT_189085
Disease pathway
REACT_217323
Integration of energy metabolism pathway
REACT_188937
Metabolism pathway
REACT_246505
Pentose phosphate pathway (hexose monophosphate shunt) pathway
REACT_203949
Glycogen storage diseases pathway
REACT_203841
Myoclonic epilepsy of Lafora pathway
REACT_248571
Metabolism of carbohydrates pathway
KEGG
mmu00030
Pentose phosphate pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_1859
Pentose phosphate pathway (hexose monophosphate shunt) pathway
REACT_939
Insulin effects increased synthesis of Xylulose-5-Phosphate pathway
REACT_1505
Integration of energy metabolism pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_111217
Metabolism pathway
REACT_116125
Disease pathway
REACT_200833
Glycogen storage diseases pathway
KEGG
hsa00030
Pentose phosphate pathway pathway
INOH
INOH website
Pentose phosphate cycle pathway
PID NCI
Cross-References
SwissProt P40142
TrEMBL
UniProt Splice Variant
Entrez Gene 21881
UniGene Mm.290692
RefSeq NM_009388
OMIM
CCDS CCDS26894
HPRD
IMGT
MGI ID MGI:105992
MGI Symbol Tkt
EMBL AF195533 AK002627 AK012794 AK030446 AK140965 AK144146 AK146157 AK150139 AK150769 AK150844 AK150856 AK152460 AK159922 AK167084 BC055336 U05809 U90889
GenPept AAC52443 AAC53570 AAG28459 AAH55336 BAB22242 BAB28474 BAC26968 BAE24531 BAE25728 BAE26940 BAE29335 BAE29835 BAE29902 BAE29911 BAE31238 BAE35484 BAE39242
RNA Seq Atlas 21881

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca