InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sash3

Summary

InnateDB Protein

IDBP-143032.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sash3

Protein Name

SAM and SH3 domain containing 3

Synonyms

1200013B08Rik; AW413946; SLY1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033427

InnateDB Gene

IDBG-143030 (Sash3)

Protein Structure

UniProt Annotation

Function

May function as a signaling adapter protein in lymphocytes. {ECO:0000269PubMed:11470164}.

Subcellular Localization

Disease Associations

Tissue Specificity

Preferentially expressed in lymphoid tissues. Expressed in bone marrow, thymus, spleen, lymph nodes and Peyer patches of gut. In the spleen and lymph nodes, expressed in both T- and B-cells. In the thymus, in the medulla and cortex. {ECO:0000269PubMed:11470164}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002639	positive regulation of immunoglobulin production
GO:0002726	positive regulation of T cell cytokine production
GO:0002821	positive regulation of adaptive immune response
GO:0030890	positive regulation of B cell proliferation
GO:0032729	positive regulation of interferon-gamma production
GO:0032733	positive regulation of interleukin-10 production
GO:0032743	positive regulation of interleukin-2 production
GO:0032753	positive regulation of interleukin-4 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0042102	positive regulation of T cell proliferation
GO:0043372	positive regulation of CD4-positive, alpha-beta T cell differentiation
GO:0046622	positive regulation of organ growth
GO:0048873	homeostasis of number of cells within a tissue
GO:0051251	positive regulation of lymphocyte activation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1921381

InterPro

IPR001452 SH3 domain
IPR001660 Sterile alpha motif domain
IPR011510 Sterile alpha motif, type 2
IPR011511 Variant SH3 domain
IPR013761 Sterile alpha motif/pointed domain
IPR021090 SAM/SH3 domain-containing
IPR021129 Sterile alpha motif, type 1

PFAM

PF00018
PF14604
PF07647
PF07653
PF12485
PF00536

PRINTS

PR00452

PIRSF

SMART

SM00326
SM00454

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt