Version 5.4
Mus musculus Gene: Sash3
Summary
InnateDB Gene IDBG-143030.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sash3
Gene Name SAM and SH3 domain containing 3
Synonyms 1200013B08Rik; AW413946; SLY1
Species Mus musculus
Ensembl Gene ENSMUSG00000031101
Encoded Proteins
IDBP-143032
SAM and SH3 domain containing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000122122:
The protein encoded by this gene contains a Src homology-3 (SH3) domain and a sterile alpha motif (SAM), both of which are found in proteins involved in cell signaling. This protein may function as a signaling adapter protein in lymphocytes.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome X:48146436-48161565
Strand Forward strand
Band A5
Transcripts
ENSMUST00000033427 ENSMUSP00000033427
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0002639 positive regulation of immunoglobulin production
GO:0002726 positive regulation of T cell cytokine production
GO:0002821 positive regulation of adaptive immune response
GO:0030890 positive regulation of B cell proliferation
GO:0032729 positive regulation of interferon-gamma production
GO:0032733 positive regulation of interleukin-10 production
GO:0032743 positive regulation of interleukin-2 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032760 positive regulation of tumor necrosis factor production
GO:0042102 positive regulation of T cell proliferation
GO:0043372 positive regulation of CD4-positive, alpha-beta T cell differentiation
GO:0046622 positive regulation of organ growth
GO:0048873 homeostasis of number of cells within a tissue
GO:0051251 positive regulation of lymphocyte activation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000122122
View Gene Order
ENSBTAG00000002041
Not yet available
Cross-References
SwissProt Q8K352
TrEMBL
UniProt Splice Variant
Entrez Gene 74131
UniGene Mm.416232
RefSeq NM_028773 XM_006541550
OMIM
CCDS CCDS40959
HPRD
IMGT
MGI ID MGI:1921381
MGI Symbol Sash3
EMBL AJ306422 AK004734 AK156202 AK171017 BC028773
GenPept AAH28773 BAB23516 BAE33623 BAE42187 CAC67499
RNA Seq Atlas 74131

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca