InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ehmt1

Summary

InnateDB Protein

IDBP-143057.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ehmt1

Protein Name

euchromatic histone methyltransferase 1

Synonyms

9230102N17Rik; D330003E03; Eu-HMTase1; GLP; GLP1; KMT1D; mKIAA1876;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000088906

InnateDB Gene

IDBG-143051 (Ehmt1)

Protein Structure

UniProt Annotation

Function

Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non- histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. {ECO:0000269PubMed:15774718, ECO:0000269PubMed:18818694}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15774718}. Chromosome {ECO:0000269PubMed:15774718}. Note=Associates with euchromatic regions.

Disease Associations

Tissue Specificity

Ubiquitous. {ECO:0000269PubMed:15774718}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	14 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0018024	histone-lysine N-methyltransferase activity

Biological Process

GO:0034968

histone lysine methylation

Cellular Component

GO:0005634

nucleus

Protein Structure and Domains

PDB ID

MGI:1924933

InterPro

IPR001214 SET domain
IPR002110 Ankyrin repeat
IPR003606 Pre-SET zinc-binding sub-group
IPR007728 Pre-SET domain
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00856
PF00023
PF13606
PF05033
PF11929
PF12796

PRINTS

PR01415

PIRSF

SMART

SM00317
SM00248
SM00468

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt