Version 5.4
Mus musculus Gene: Ehmt1
Summary
InnateDB Gene IDBG-143051.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ehmt1
Gene Name euchromatic histone methyltransferase 1
Synonyms 9230102N17Rik; D330003E03; Eu-HMTase1; GLP; GLP1; KMT1D; mKIAA1876
Species Mus musculus
Ensembl Gene ENSMUSG00000036893
Encoded Proteins
IDBP-143053
euchromatic histone methyltransferase 1
IDBP-143055
euchromatic histone methyltransferase 1
IDBP-143057
euchromatic histone methyltransferase 1
IDBP-251761
euchromatic histone methyltransferase 1
IDBP-251763
euchromatic histone methyltransferase 1
IDBP-536815
euchromatic histone methyltransferase 1
IDBP-542255
euchromatic histone methyltransferase 1
IDBP-534992
euchromatic histone methyltransferase 1
IDBP-535692
euchromatic histone methyltransferase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000181090:
The protein encoded by this gene is a histone methyltransferase that is part of the E2F6 complex, which represses transcription. The encoded protein methylates the Lys-9 position of histone H3, which tags it for transcriptional repression. This protein may be involved in the silencing of MYC- and E2F-responsive genes and therefore could play a role in the G0/G1 cell cycle transition. Defects in this gene are a cause of chromosome 9q subtelomeric deletion syndrome (9q-syndrome). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:24790769-24919609
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000102938 ENSMUSP00000100002
ENSMUST00000046227 ENSMUSP00000046077
ENSMUST00000091348 ENSMUSP00000088906
ENSMUST00000114432 ENSMUSP00000110075
ENSMUST00000114418 ENSMUSP00000110061
ENSMUST00000147147 ENSMUSP00000119057
ENSMUST00000134775
ENSMUST00000138805
ENSMUST00000152636
ENSMUST00000144672
ENSMUST00000150836
ENSMUST00000139000
ENSMUST00000152325 ENSMUSP00000123387
ENSMUST00000152161 ENSMUSP00000119854
ENSMUST00000150379 ENSMUSP00000123187
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 14 [view]
Protein-DNA 4 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 27 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0016279 protein-lysine N-methyltransferase activity
GO:0018024 histone-lysine N-methyltransferase activity
GO:0046974 histone methyltransferase activity (H3-K9 specific)
GO:0046976 histone methyltransferase activity (H3-K27 specific)
GO:0070742 C2H2 zinc finger domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006306 DNA methylation
GO:0009790 embryo development
GO:0016568 chromatin modification
GO:0016571 histone methylation
GO:0018026 peptidyl-lysine monomethylation
GO:0018027 peptidyl-lysine dimethylation
GO:0034968 histone lysine methylation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0051567 histone H3-K9 methylation
GO:0070734 histone H3-K27 methylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000181090
View Gene Order
ENSBTAG00000012148
Not yet available
Pathways
NETPATH
REACTOME
REACT_188957
Cellular responses to stress pathway
REACT_188820
Cellular Senescence pathway
REACT_206033
Senescence-Associated Secretory Phenotype (SASP) pathway
KEGG
mmu00310
Lysine degradation pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_169274
Cellular Senescence pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
KEGG
hsa00310
Lysine degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.24176
RefSeq NM_001012518 NM_001109686 NM_001109687 NM_172545 XM_006498422 XM_006498423 XM_006498424 XM_006498425 XM_006498426 XM_006498427 XM_006498428 XM_006498429 XM_006498430 XM_006498431 XM_006498432
OMIM
CCDS CCDS15740 CCDS59634 CCDS59635 CCDS59636
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca