Version 5.4
Homo sapiens Protein: SKA3
Summary
InnateDB Protein IDBP-14310.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SKA3
Protein Name spindle and kinetochore associated complex subunit 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000298260
InnateDB Gene IDBG-14308 (SKA3)
Protein Structure
UniProt Annotation
Function Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the microtubule-stimulated oligomerization. {ECO:0000269PubMed:19289083, ECO:0000269PubMed:19360002}.
Subcellular Localization Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0031110 regulation of microtubule polymerization or depolymerization
Cellular Component
GO:0000940 condensed chromosome outer kinetochore
GO:0005737 cytoplasm
GO:0005876 spindle microtubule
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IX90
PhosphoSite PhosphoSite-Q8IX90
TrEMBL
UniProt Splice Variant
Entrez Gene 221150
UniGene Hs.88523
RefSeq XP_005266345
HUGO HGNC:20262
OMIM
CCDS
HPRD 10706
IMGT
EMBL AF361358 AK090584 AK314864 AL158032 BC013418 BC048988 CH471075
GenPept AAH13418 AAH48988 AAO13796 BAC03484 BAG37379 CAH69950 CAM13059 CAM13060 EAX08293 EAX08294 EAX08295

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca