Version 5.4
Homo sapiens Gene: SKA3
Summary
InnateDB Gene IDBG-14308.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SKA3
Gene Name spindle and kinetochore associated complex subunit 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165480
Encoded Proteins
IDBP-14310
spindle and kinetochore associated complex subunit 3
IDBP-14312
spindle and kinetochore associated complex subunit 3
IDBP-229235
spindle and kinetochore associated complex subunit 3
IDBP-583563
spindle and kinetochore associated complex subunit 3
IDBP-592773
spindle and kinetochore associated complex subunit 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a component of the spindle and kinetochore-associated protein complex that regulates microtubule attachment to the kinetochores during mitosis. The encoded protein localizes to the outer kinetechore and may be required for normal chromosome segregation and cell division. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:21153595-21176602
Strand Reverse strand
Band q12.11
Transcripts
ENST00000298260 ENSP00000298260
ENST00000314759 ENSP00000319417
ENST00000400018 ENSP00000382896
ENST00000462482 ENSP00000443543
ENST00000465471 ENSP00000441632
ENST00000475251
ENST00000536239
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007059 chromosome segregation
GO:0007067 mitotic nuclear division
GO:0031110 regulation of microtubule polymerization or depolymerization
Cellular Component
GO:0000940 condensed chromosome outer kinetochore
GO:0005737 cytoplasm
GO:0005876 spindle microtubule
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021965
View Gene Order
ENSBTAG00000003314
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.88523
RefSeq NM_001166017 NM_145061 XM_005266288
HUGO
OMIM
CCDS CCDS31946 CCDS53856
HPRD 10706
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca