Version 5.4
Mus musculus Protein: Itih4
Summary
InnateDB Protein IDBP-143375.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Itih4
Protein Name inter alpha-trypsin inhibitor, heavy chain 4
Synonyms ITI-HC4; Itih-4;
Species Mus musculus
Ensembl Protein ENSMUSP00000006703
InnateDB Gene IDBG-143373 (Itih4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005515 protein binding
Biological Process
GO:0006953 acute-phase response
GO:0010951 negative regulation of endopeptidase activity
GO:0030212 hyaluronan metabolic process
GO:0034097 response to cytokine
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID MGI:109536
InterPro IPR002035 von Willebrand factor, type A
IPR010600 Inter-alpha-trypsin inhibitor heavy chain, C-terminal
IPR013694 VIT domain
PFAM PF00092
PF06668
PF08487
PF13757
PRINTS
PIRSF
SMART SM00327
SM00609
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A6X935
PhosphoSite PhosphoSite-A6X935
TrEMBL
UniProt Splice Variant
Entrez Gene 16427
UniGene Mm.415981
RefSeq NP_061216
MGI ID
MGI Symbol Itih4
OMIM
CCDS CCDS26901
HPRD
IMGT
EMBL AF023919 AK004893 AK050016 AK050270 BC016500 BC092258 BC094457 CH466573 CT025528
GenPept AAC25786 AAH16500 AAH92258 AAH94457 BAB23649 BAC34032 BAC34155 CAO78004 CAO78005 EDL24772

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca