InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fen1

Summary

InnateDB Protein

IDBP-143514.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fen1

Protein Name

flap structure specific endonuclease 1

Synonyms

AW538437; FEN-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025651

InnateDB Gene

IDBG-143512 (Fen1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003677	DNA binding
GO:0003824	catalytic activity
GO:0004518	nuclease activity
GO:0004523	RNA-DNA hybrid ribonuclease activity
GO:0004527	exonuclease activity
GO:0005515	protein binding
GO:0008409	5'-3' exonuclease activity
GO:0017108	5'-flap endonuclease activity
GO:0030145	manganese ion binding
GO:0048256	flap endonuclease activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0006260	DNA replication
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0007613	memory
GO:0043137	DNA replication, removal of RNA primer
GO:0090305	nucleic acid phosphodiester bond hydrolysis
GO:0090502	RNA phosphodiester bond hydrolysis, endonucleolytic

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005739	mitochondrion
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:102779

InterPro

IPR006085 XPG N-terminal
IPR006086 XPG-I domain
IPR008918 Helix-hairpin-helix motif, class 2
IPR020045 5\'-3\' exonuclease, C-terminal domain
IPR029060 PIN domain-like

PFAM

PF00752
PF00867
PF01367
PF09293

PRINTS

PIRSF

SMART

SM00485
SM00484
SM00279

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite