InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dagla

Summary

InnateDB Protein

IDBP-143683.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dagla

Protein Name

diacylglycerol lipase, alpha

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000046358

InnateDB Gene

IDBG-143681 (Dagla)

Protein Structure

UniProt Annotation

Function

Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed by principal cells in the hyppocampus. In embryonic brains, it is present in axonal tracts, while in adults it localizes to dendritic fields, correlating with the developmental change in requirement for 2-AG synthesis from the pre- to the postsynaptic compartment. Concentrated in heads of dendritic spines throughout the hippocampal formation. Highly compartmentalized into a wide perisynaptic annulus around the postsynaptic density of axospinous contacts but not intrasynaptically (at protein level). {ECO:0000269PubMed:14610053, ECO:0000269PubMed:16723519}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004806	triglyceride lipase activity
GO:0046872	metal ion binding

Biological Process

GO:0006629	lipid metabolic process
GO:0007405	neuroblast proliferation
GO:0019369	arachidonic acid metabolic process
GO:0022008	neurogenesis
GO:0042136	neurotransmitter biosynthetic process
GO:0046340	diacylglycerol catabolic process
GO:0071926	endocannabinoid signaling pathway